Aspects of this topic are discussed in the following places at Britannica.
...of certain individuals to react to a chemical. Because of biological variability among humans, some individuals respond to a chemical at a dose too low to produce a similar effect in others. Idiosyncrasy is a genetically determined hypersusceptibility.
...dosage, and effects that are unrelated to the basic action of the drug and occur in only a small proportion of individuals, irrespective of the dose given. Effects of the latter type are known as idiosyncratic effects and include some very severe reactions, such as sudden cardiovascular collapse or irreversible suppression of blood cell production. Some reactions of this type have an allergic...
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